Aurisco Pharmaceutical Co., Ltd.

EN

CN EN

Oligonucleotide CRO&CDMO

Shanghai Aurisco Biotech Co., Ltd is focus on providing CRO/CDMO services. We provide APIs service from discovery, clinical trials to commercial stage.

With 20+ years’ experience of API manufacturing, our oligo platform has a dedicated team of 30+ scientists in oligonucleotide field,and equips with advanced and equipment,accelerating clients’ drugs to the global market.

The process chemistry, analytical, and regulations teams collaborate to provide clients with a fast, efficient, and flexible integrated solution for oligonucleotide development.

Advanced equipments

Aurisco oligonucleotide platform is equipped with Cytiva ÄKTA oligonucleotide solid-phase synthesizer and purification equipment,with capacity from gram to KG scale.

In addition, analytical equipments including UPLC-QTof, UPLC-MS, UPLC provide support for oligonucleotide structure characterization, analytical method development and validation,GMP manufacturing and stability study.

Lab scale(grams)
ÄKTA OligoPilot 10ÄKTA OligoPilot 100ÄKTA Pure 25ÄKTA Pure 150ÄKTA flux 6Lyophilyzer Xinzhi
Pilot scale (hundreds grams)
OligoPilot™ 2000Novasep Hipersep™Sartoflow advancedGenesis 35L
Key analytical equipment
UHPLC,UPLC(IP-RP, IEX, SEC)LC-MS(ESI, Quadrupole)UPLC-HRMS(ESI, Q-tof)Headspace GCUV-VIS(Temperature controlled)

Manufacturing capability

Custom DNA/RNA - API Manufacturing Services

Aurisco provides oligonucleotide synthesis services as follow

01ASO
02siRNA
03Aptamer
04CpG ODN
05Other new oligos
06Oligos Conjugations
07Others：modified nucleoside，impurity, modified GalNAc or Lipid

Oligonucleotide Service includes

Process Developing and Optimization
mg to KG scale
Analytical characterization, test method development and validation, IPC & release testing
Stability studies compliant to ICH
RA support for worldwide